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A punch biopsy at the border of the lesion is necessary to rule out melanosis secondary to malignant melanoma that manifests as a generalized blue-gray skin discoloration.
Erythema toxicum neonatorum, transient neonatal pustular melanosis , sucking blister, miliaria, and mongolian spots are among the many benign skin conditions that can occur in newborns.
Adrenal insufficiency was suspected when five of the following features were present: weight loss, general weakness, anorexia, diarrhoea, melanosis , postural hypotension, hyponatraemia and hyperkalaemia.
Beyond this observation in 4 patients, we know of no other reports in the English literature of melanosis pigment in the pericolonic lymph nodes of patients with melanosis coli.
Various types of skin manifestations of arsenic toxicity were observed - from melanosis , keratosis, hyperkeratosis, dorsal keratosis, and nonpitting edema, to gangrene and cancer.
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