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This results in female mosaicism for loci located in the differential chromosome region.
High rates of structural instability have in fact been reported for palindromic transgenes in mice, where mitotic mosaicism and rearranged versions of the transgene have been detected in the progeny.
This can be explained on the basis of germline or gonadal mosaicism .
Androgens could be implicated in the earlier death of males, but recent studies suggest that female mosaicism may enhance lifespan.
We propose that both controls are general and do not constitute a novel ‘switch’ that enables sexual mosaicism in hermaphrodites.
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