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Although valerian's action is comparable to the barbiturate phenobarbital , it doesn't cause the next-day dizziness, blurred vision, drowsiness or decreased concentration associated with barbiturates.
All of the women included in the case part of the study were taking at least one of the following folic acid antagonists: trimethoprim, triamterene, sulfasalazine, phenytoin, phenobarbital , primidone and carbamazepine.
It is well known that many drugs such as benzodiazepines and phenobarbital possess anxiolytic and sedative effects.
Carbamazepine, phenobarbital and phenytoin are commonly prescribed for the management of epilepsy and other disorders.
Before 1990, six major AEDs were available for the treatment of all forms of epilepsy: carbamazepine, phenobarbital , phenytoin, primidone, valproic acid, and ethosuximide.
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